Marie Skłodowska-Curie Actions

PhD student – Early Stage Researcher: Bioenergetics of human osteoblasts

This job offer has expired

    University of Southern Denmark
    Biological sciencesBiology
    Medical sciencesMedicine
    First Stage Researcher (R1)
    28/10/2019 12:00 - Europe/London
    Denmark › Odense
    H2020 / Marie Skłodowska-Curie Actions

The EU-funded Innovative Training Network FIDELIO (https://fidelio-project.eu) aims to train
the next generation of scientists in order to tackle the challenges of diabetic bone disease
from various angles and with the newest technologies available. Interdisciplinary training and
implementation of innovative approaches are key. Within this consortium, we will
comprehensively unravel the genetic and environmental mechanisms that contribute to bone
fragility in diabetes, identify predictors and clinical markers for patient stratification, decipher
the underlying molecular mechanisms of bone fragility in diabetes, and establish potential
interventions through a personalised medicine approach.
The research programme will address different aspects of diabetic bone disease from the
viewpoints of epidemiology, genetics, miRNAs, microbiome, bone biology, bone
biomechanics and microstructure, preclinical and clinical research. It will utilise advanced
imaging and computational approaches, diabetes mouse models and access to clinical
cohorts and registry data to obtain a comprehensive overview of how these mechanisms
combine in diabetes to cause increased fracture risk.
With this interdisciplinary approach, we can explore the impact of biological pathways in
mouse models and/or humans, and interactions with diet, exercise and other exposures.
Collaborations with industry will allow early identification of IP, access to state of the art
technologies, and will complement the academic ESR training programme with
entrepreneurship and industrial mentoring.
Your PhD project:
One Phd project will examine the cellular and molecular phenotype of human skeletal (MSC)
and osteoblastic cultures established from bone marrow aspirates obtained from patients
with T1D/T2D and healthy, age-matched controls and include ex vivo cell proliferation,
osteoblastic and adipocytic differentiation, molecular phenotyping using RNA-seq. Ex vivo
metabolic studies of bioenergetics will be included e.g. measuring glycolysis and OXPHOS.
The role of miRNA species in regulating energy metabolism will be determined using either
global miRNA gene expression analysis or focused analysis of miRNAs.
One Phd project is based on epidemiological analysis of the effect of metformin in bone
outcomes and fracture. Metformin use in relation to fracture risk will be examined in the
registry of Statistics Denmark and compared with the findings in the Rotterdam Study.
You will embark on secondments to other FIDELIO partners TamiRNA (AT) or ERASMUS to
access experimental models or tools or receive training not available in the home laboratory.
Total secondment time is 3 months.


· You will be working within our international group of > 30 researchers with experience
in a broad range of sciences
· You will get in contact with the other members of this international consortium and will
benefit from the joint training platform to develop skills necessary for developing a
thorough understanding of the mechanisms of Diabetes and the bone metabolism
and for obtaining industry skills.
· You will be employed by the host organization for 36 months.
· A competitive salary plus allowances. Moreover, funding is available for technical and
personal skills training and participation in international research events.
· You will benefit from the designed training program offered by the host organization and
the consortium.
· You will participate in international conferences and secondments to other organizations
within the FIDELIO network and in outreach activities targeted at a wide audience
Please find additional information in the Information package for Marie Curie fellows

Selection process

Planned key dates:
25 November 2019: Recruitment event in Rome, Italy

Web site for additional job details

Offer Requirements

    ENGLISH: Excellent


· Applicants must hold a MSc or equivalent in the field of biology, medicine, chemistry or a related discipline
· Applicants must have a solid knowledge of cell and molecular biology as well as biochemistry. Experience with animal experimentation is desired. Willingness to work with animals is a prerequisite
· For epidemiological studies, having a medical degree is very relevant · Applicants can be of any nationality
· Applicants must have an ability to understand and express themselves in both written and spoken English to a level that is sufficiently high for them to derive the full benefit from the network training
· Applicants must be eligible to enroll on a PhD program at the host institution SDU
In addition:
H2020 MSCA Mobility Rule: researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of the host organization (Denmark) for more than 12 months in the 3 years immediately before the recruitment date. Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status are not taken into account. Eligible researchers must not have spent more than 12 months in the 3 years immediately prior to the date of selection in the same appointing international organisation.
H2020 MSCA eligibility criteria:
Early Stage Researchers (ESRs) must, at the date of recruitment by the host organization, be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree. Full-Time Equivalent Research Experience is measured from the date when the researcher obtained the degree entitling him/her to embark on a doctorate (either in the country in which
the degree was obtained or in the country in which the researcher is recruited, even if a doctorate was never started or envisaged).

Work location(s)
1 position(s) available at
University of Southern Denmark

EURAXESS offer ID: 447765


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