ORGANISATION/COMPANYmuséum national d'histoire naturelle
RESEARCH FIELDBiological sciences › Biology
RESEARCHER PROFILEFirst Stage Researcher (R1)Recognised Researcher (R2)
APPLICATION DEADLINE31/12/2019 21:00 - Europe/Brussels
LOCATIONFrance › paris
TYPE OF CONTRACTTemporary
HOURS PER WEEK35
OFFER STARTING DATE01/02/2020
EU RESEARCH FRAMEWORK PROGRAMMEH2020
Postdoctoral Fellow – Drug screening, metabolism and host-parasite interactions.
A post-doctoral position is available in the Parasites et Protistes Libres (PPL) / Parasites and Free Living Protists team of the Natural History Museum of Paris, CNRS UMR 7245.The PPL team has a long-standing activity in parasite diversity, with a focus on Apicomplexa, Trypanosomatidae and filarial Nematodes. Complementary to this approach, the team is developing basic research projects to try to understand the molecular mechanisms involved in host-filariae interactions.
This post-doctoral project will participate to the Helminth Drug Development Platform (HELP), a multidisciplinary platform, bringing together academic and industry research teams, from European and disease-endemic countries as well as a product development partnership. The participant research teams are key players in the field of anthelmintic drug discovery and development for neglected tropical diseases to ultimately develop nematode treatments at affordable cost and made available in affected countries. The overall objective is to establish a pipeline of anthelmintic drug development and advance at least one pan-nematode candidate targeting multiple nematodes, one for STH and one for filarial infections.
We seek for a Postdoctoral Fellow to run a thorough in vitro and in vivo evaluation of a selection of compounds with filaricidal activity demonstrated in phenotypic screens. These compounds will be evaluated in rodent models of filariasis. Furthermore, the successful candidate will be able to combine advanced live cell imaging, protein and metabolite profiling, and genomic screening with molecular and biochemical approaches to identify mechanisms of actions of lead compounds.
This position is available for 2 years starting first trimester 2020.
Please contact Dr Martin by email: firstname.lastname@example.org with:
1. A cover letter that discusses your interest in the position, past research experience and scientific achievements, and future research interests
2. Your CV including a list of publications and the contact information for 2-3 referees
Candidates should possess a PhD in cell/molecular biology and parasitology with prior experience in one or more of the following methodologies: helminth maintenance, mammalian cell culture, protein and RNA analysis, confocal microscopy, or infection mouse models. Additional metabolomic experience (NMR spectroscopy or mass-spectrometry) is preferred. Skills in statistics for metabolomics would be also appreciated but not mandatory. The working language is English.
Candidates must have a high level of motivation, demonstrate a track record of consistent publication, have strong organizational, written, and oral communication skills and be able to work both independently and as part of a team.
EURAXESS offer ID: 462103
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