05/12/2019

The regulation of adult neurogenesis by astrocytes

This job offer has expired


  • ORGANISATION/COMPANY
    CHUV - Hôpital Universitaire de Lausanne
  • RESEARCH FIELD
    Biological sciencesBiology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
    Recognised Researcher (R2)
    Established Researcher (R3)
    Leading Researcher (R4)
  • APPLICATION DEADLINE
    04/03/2020 00:00 - Europe/Athens
  • LOCATION
    Switzerland › Lausanne
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time

OFFER DESCRIPTION

Adult hippocampal neurogenesis is the most drastic form of brain plasticity and it is involved in mechanisms of learning and memory, as well as anxiety and depression. Thus, the mechanisms of regulation of adult neurogenesis are highly relevant for neurodegenerative diseases or mood disorders. 

The goal of this project is to understand the role of astrocytes in the regulation of adult neurogenesis. In particular, we are focusing on molecules released by astrocytes, that regulate stem cell proliferation and neuronal differentiation in the context of learning of memory.

The techniques used will include cell biology (cell culture, signaling, viral-mediated gene transfer, inducible transgenic mice), histology (tissue preparation, image analysis, confocal microscopy), behavior (memory, anxiety, depression), biochemistry (mass spectrometry, purification methods),...

This project is a follow up of the following : Sultan et al Neuron 2015 (PMID 26606999). More info can also be found in the following review: Cassé et al. Frontiers 2018 (PMID 30538622).



Funding category: Financement public/privé



PHD title: Doctorat de Neurosciences

PHD Country: Suisse

More Information

Offer Requirements

Specific Requirements

We are looking for a highly motivated PhD student in neuroscience.

We will only consider applications from biology students with a master in neuroscience. Preference will be given to candidates who have experience with histology, biochemistry or behavioral analyses.

The candidate is a team player, has strong skills in verbal and written communication (English required, French is an asset), works independently, but is eager to collaborate with other members of the team.

Work location(s)
1 position(s) available at
CHUV - Hôpital Universitaire de Lausanne
Switzerland
Lausanne

EURAXESS offer ID: 470123
Posting organisation offer ID: 88904

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