RESEARCHER PROFILEFirst Stage Researcher (R1)Recognised Researcher (R2)
APPLICATION DEADLINE24/02/2020 00:00 - Europe/Brussels
LOCATIONNetherlands › Nijmegen
TYPE OF CONTRACTTemporary
HOURS PER WEEK40.0
Are you an ambitious postdoc interested in building a synthetic cell? Join our strong team!
Our research focuses on understanding the role of liquid-liquid phase separation in the organisation, control and direction of biomolecular processes in cells. Ultimately, we aim to use these insights to create dynamic membrane-free compartments in synthetic cells to control the availability, folding and reactivity of biomolecules in space and time. The current emphasis is on developing populations of coexisting phase-separated compartments that can sequester RNA or proteins depending on their primary or secondary structure.
As a postdoc you will work on building a synthetic cell equipped with dynamic, membrane-free compartments inspired by membraneless organelles found in living cells. These artificial organelles will help direct enzymatic and genetic reaction networks in vitro, by acting as super-enhancers or reaction hotspots. You will design and test new protein constructs that undergo liquid-liquid phase separation and sequester specific biomolecules, and study their role in enhancing transcription, protein folding and oligomerisation. Ultimately, you will create a genetic toolbox that encodes all components of synthetic organelles in a synthetic cell. Throughout the project, you will work extensively with cell-free synthetic biology, fluorescence microscopy and microscopy-based material analysis, state-of-the-art microfluidic tools, and mathematical modelling techniques.
For more information, see www.spruijtlab.com & Front. Mol. Biosci. 2019, 6, 21; Nature Nanotechnology 2018, 13, 849; Soft Matter 2018, 14, 361; Nature Nanotechnology 2016, 11, 191.
- Employment: 32 - 40 hours per week.
- A maximum gross monthly salary of € 4.274 based on a 38-hour working week (salary scale 10).
- The exact salary depends on the candidate's qualifications and amount of relevant professional experience.
- In addition to the salary: an 8% holiday allowance and an 8.3% end-of-year bonus.
- Duration of the contract: 1 year, with a possible extension to 3 years.
- The intended start date is 1 April 2020.
- You will be able to make use of our Dual Career Service: our Dual Career Officer will assist with family-related support, such as child care, and help your partner prepare for the local labour market and with finding an occupation.
- Are you interested in our excellent employment conditions?
Please address your application to Evan Spruijt and submit it, using the application button, no later than 23 February 2020, 23:59 Amsterdam Time Zone.
Your application should include the following attachments:
- Motivation letter.
For more information about this vacancy, please contact:
Evan Spruijt, PI
Web site for additional job details
- A PhD degree in chemical biology, biochemistry, biophysics or a related field.
- You have experience in molecular biology (cloning, transformation of bacteria and culturing) and working with proteins. Experience in fluorescence microscopy and/or quantitative image analysis would be an advantage.
- You have excellent communication skills and the willingness to work in a dynamic, international research team.
- You are proficient in written and spoken English.
- You are creative, have an analytical mindset, and want to work at the forefront of science.
- You are a team player.
EURAXESS offer ID: 482201
Posting organisation offer ID: 288984
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