17/01/2020

PhD student at the Tracer Center Amsterdam Department of Radiology & Nuclear Medicine


  • ORGANISATION/COMPANY
    VU university medical center (VUmc)
  • RESEARCH FIELD
    Medical sciences
    Physics
    Technology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    27/02/2020 23:59 - Europe/Brussels
  • LOCATION
    Netherlands › Amsterdam
  • TYPE OF CONTRACT
    Permanent
  • HOURS PER WEEK
    36.0

The PhD student position is available at the Tracer Center Amsterdam, Department of Radiology & Nuclear Medicine of VUmc, The Netherlands, with an anticipated start in March 2020.
The stipend is funded by the European Union’s Horizon 2020 research and innovation programme under the Innovative Medicines Intiative (IMI) grant agrement, the project is called “Immune-Image: Specific Imaging of Immune Cell Dynamics Using Novel Tracer Strategies”.

Your challenge

Immune check point inhibitors have been shown to be effective only in a subset of cancer patients. Predicting patient benefit by using currently approved diagnostics is challenging, as biopsy-based tests are not reliable due to the heterogeneity of the tumors and limitations of invasive tissue collection. Noninvasive imaging technologies, particularly positron emission tomography (PET), have the potential to quantify target expression levels provided that a tracer is available.

The candidate will work on developing novel peptide-based molecules for PET imaging. You will use different approaches like phage display and computational modeling to identify lead compounds. You will synthesize them and evaluate them in vitro for affinity, specificity and stability, and you will further optimize them to improve their characteristics. You will also radiolabel them with different isotopes for in vitro and in vivo evaluation, and PET imaging.

The candidates will be enrolled at the CCA graduate school of VUmc. The graduate program requires the student to obtain 30 ECTS points during the PhD trajectory in order to graduate.

Benefits

Salary Scale PHD: 2422 tot 3103 euro gross when employed full-time (depending on qualifications and experience).

  • Additional benefits include an 8.3% end-of-year bonus and 8% holiday pay;
  • Your pension premium will be paid by us for 2/3; 
  • We reimburse 75% of your OV travel costs (commuting costs).

What we also offer
We offer you the opportunity to further develop your skills, to deepen and broaden your knowledge, and to follow additional training. Working at Amsterdam UMC means working in an inspiring and professional environment where development is encouraged in every respect.

For more information about our employment conditions, please visit our website.

For Dutch citizens it is mandatory to provide a VOG (a declaration of good behaviour).

Additional comments

The application must include a motivation letter, a curriculum vitae, a list of peer reviewed publications, as well as possible letters of recommendation and diplomas.

Don’t hesitate to call us!

If you’re interested about this position, you can contact dr. W. Beaino at +3120444 5544 or alternatively Prof. dr. A.D. Windhorst, via telephone number +3120 444 9707.

If you need more information about the application procedure, contact Brend de Jong, corporate recruiter at +3120 444 5635.

You can apply till 27 February 2020 by using the apply button.

Acquisition based on this vacancy is not appreciated.

Web site for additional job details

Offer Requirements

Specific Requirements

We are looking for a dedicated and skilled individual with excellent analytical skills, good command of written and spoken English and the candidate should be able to work in a team as well as independently.

You also have the preferred following qualifications:

  • Obtained a MSc degree in biochemistry, chemical biology, medicinal chemistry or life sciences;
  • Experience in computational modeling;
  • Experience in phage display and bacterial culture;
  • Experience in peptide chemistry or organic chemistry;
  • Experience in cell culture and in vitro binding assays;
  • Interest in molecular imaging and PET imaging.

Map Information

Job Work Location Personal Assistance locations
Work location(s)
1 position(s) available at
VU university medical center (VUmc)
Netherlands
Amsterdam
1081 HZ
De Boelelaan 1116

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EURAXESS offer ID: 482203
Posting organisation offer ID: 288979

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